Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety

Authors

  • Ahmad Reza Mehdipour Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Medicinal Chemistry, Faculty of Pharmacy, Shiraz University of Medical Sciences, PO Box 71345-1149, Shiraz , Iran.
  • Katayoun Javidnia Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Medicinal Chemistry, Faculty of Pharmacy, Shiraz University of Medical Sciences, PO Box 71345-1149, Shiraz , Iran.
  • Ramin Miri Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Medicinal Chemistry, Faculty of Pharmacy, Shiraz University of Medical Sciences, PO Box 71345-1149, Shiraz , Iran.
  • Savis Meili Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Medicinal Chemistry, Faculty of Pharmacy, Shiraz University of Medical Sciences, PO Box 71345-1149, Shiraz , Iran.
  • Seyyed Hossein Salimi Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Medicinal Chemistry, Faculty of Pharmacy, Shiraz University of Medical Sciences, PO Box 71345-1149, Shiraz , Iran.
  • Zahra AmirGhofran Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Immunology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Zahra Sabetghadam Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Medicinal Chemistry, Faculty of Pharmacy, Shiraz University of Medical Sciences, PO Box 71345-1149, Shiraz , Iran.
Abstract:

The 1,4-dihydropyridine (DHP) derivatives are a known class of calcium channel blockers. Some derivatives of DHP showed significant cytotoxicity. It was shown that this effect may not be the result of interaction with Ca2+ channels. In this study, we performed an investigation about the intrinsic cytotoxicity of some derivatives of DHP containing nitroimidazole moiety on their C4 position on four different cancer cell lines (Raji, K562, Fen and HeLa). The result showed that these compounds had moderate-good cytotoxic activity. In addition, QSAR model show the importance of N atom in cytotoxicity; Ca2+ channels.

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Journal title

volume Volume 10  issue Number 3

pages  497- 503

publication date 2011-09-14

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